Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury

Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir...

A Novel Dissolution-Diffusion Model for Investigation of Drug Release from Polymeric Microspheres

A new model was developed for drug release from microspheres. Drug dissolution, diffusion, moving front, and size distribution were considered as main release mechanisms. The proposed dissolution-diffusion model was solved numerically for analysis of dissolved drug concentration profiles. In comparison with Fickian diffusion model and Koizumi model, the proposed model is characteristic of the w...

Free radicals and tissue injury -

Polymeric Microspheres for Medical Applications

Synthetic polymeric microspheres find application in a wide range of medical applications. Among other applications, microspheres are being used as bulking agents, embolicor drug-delivery particles. The exact composition of the spheres varies with the application and therefore a large array of materials has been used to produce microspheres. In this review, the relation between microsphere synt...

Autonomous Indication of Mechanical Damage in Polymeric Coatings.

High-resolution in situ autonomous visual indication of mechanical damage is achieved through a microcapsule-based polymeric material system. Upon mechanical damage, ruptured microcapsules release a liquid indicator molecule. A sharp color change from light yellow to bright red is triggered when the liberated indicator 2',7'-dichlorofluorescein reacts with the polymeric coating matrix.